Scarab Genomics CLEAN GENOME® E. coli is the host of choice for optimal cloning performance and production efficiency. General cloning, plasmid propagation, production of plasmid-based RNAi, DNA vaccines and recombinant protein-based therapeutics are some the many possible applications.
CLEAN GENOME® E. coli Benefits …
• Superior genomic stability - Removal of mobile insertion sequence (IS) elements, eliminates the danger of undesirable IS transposition into your clone and reduces the mutation rate of the strain itself. Genome alterations due to IS translocation occur surprisingly frequently and many commonly used laboratory strains have unrecognized transposition mediated genome alterations.
• High transformation efficiency - Among the highest transformation efficiency of commercially available Electrocompetent E. coli strains.
• Increased success cloning difficult or unclonable genes - Eliminates cloning artifacts due to IS transposition and minimizes plasmid rearrangement during propagation.
• Improved metabolic efficiency - Elimination of unnecessary genes, and its products, increases metabolic efficiency so that energy is focused on production of the target of choice, DNA or protein.
Technology and Applications