Background

Scarab Genomics was established in 2002. The Clean Genome® E. coli is the result of Dr. Fred Blattner's research at the University of Wisconsin, Madison. Scarab Genomics has licensed the patented reduced genome technology from Wisconsin Alumni Research Foundation on an exclusive, worldwide basis.

Scarab Genomics has bioengineered the Clean Genome® E. coli by deleting over 15% of the genome. Genome reduction optimizes the E. coli as a biological factory. Elimination of recombinogenic or mobile DNA, toxins and virulence genes and non-essential genes provides increased genome and plasmid stability and improved metabolic efficiency. Clean Genome® E. coli is the strain of choice for a wide spectrum of applications ranging from routine cloning to production of biopharmaceuticals.

The Significance of the Scarab

To ancient Egyptians, scarab beetles with their beautiful iridescent carapaces suitable for jewelry were talismans of good luck and represented new life. To Scarab Genomics new life comes when application of synthetic biology leads to improved E. coli strains for research and therapeutic applications.